Clinical Trials And Statistics In Orthopaedic Research


Clinical Trials And Statistics In Orthopaedic Research

Organisers: Prof Matt Costa, Dr Andrew Judge


Aim: For orthopaedic surgeons and basic scientists to further their knowledge and understanding of clinical trials and statistics in order to improve research conduct, interpretation of research studies, and translation of findings.


Outcome 1: To learn about: (a) qualitative and quantitative study design; (b) presenting a research question for interventional studies; (c ) trial research teams and (d) evidence synthesis.


Outcome 2: To gain an understanding in: (a) observational study designs; (b) statistical tests and research methods; (c) sample size calculations; (d) common designs and statistical methods used in orthopaedics


Speaker 1: Prof Matt Costa, University of Warwick


Presentation Title: Interventional studies and trial design


Speaker 2: Dr Andrew Judge, University of Oxford


Presentation Title: Introduction to statistical research methods and observational study designs


















Matt Costa is Professor of Trauma and Orthopaedic Surgery at the Warwick Clinical Trials Unit. His research interest is in clinical and cost effectiveness of musculoskeletal interventions. He is Chief Investigator for a series of randomised trials and associated studies supported by grants from the National Institute of Health Research and Musculoskeletal Charities. His clinical practice is at University Hospital Coventry and Warwickshire NHS Trust, which is a Major Trauma Centre and tertiary referral unit for orthopaedic surgery. He specialises in orthopaedic trauma surgery.


Costa ML, Achten J, Parsons NR, Edlin RP, Foguet P, Prakash U, Griffin DR.

Total hip arthroplasty versus resurfacing arthroplasty in the treatment of young patients with arthritis of the hip joint: single centre, parallel group, assessor blinded, randomised controlled trial.

BMJ 2012;344:e2147

Costa ML, Achten J, Parsons NR, Rangan A, Griffin D, Tubeuf S, Lamb SE on behalf of DRAFFT Study Group. Percutaneous fixation with Kirschner wires versus volar locking plate fixation in adults with dorsally displaced fracture of distal radius: randomised controlled trial

BMJ 2014;349:g4807
















Andrew Judge is an Associate Professor and Senior Statistician at the NIHR Musculoskeletal Biomedical Research Unit, University of Oxford. His current research interests are focused on identifying risk factors for poor patient reported outcomes (PROMs) of hip and knee replacement surgery and exploring geographical variation in the provision of healthcare and the treatment and management of patients in the NHS. He has experience in the analysis of large routine datasets including the Hospital Episode Statistics (HES) data and General Practice Research Database (GPRD), and has developed expertise in the use of Geographical Information Systems (GIS) for health research. He is a principal investigator and a co-applicant on a number of research grants.


Hunt LP, Ben-Shlomo Y, Clark EM, Dieppe P, Judge A, MacGregor AJ, Tobias JH, Vernon K, Blom AW 45-day mortality after 467,779 knee replacements for osteoarthritis from the National Joint Registry for England and Wales: an observational study Lancet. 2014 Oct; 9952(384): 1429-1436

Liddle AD, Judge A, Pandit H, Murray DW Adverse outcomes after total and unicompartmental knee replacement in 101 330 matched patients: a study of data from the National Joint Registry for England and Wales Lancet. 2014 Jul